Enoyl-Acyl-Carrier Protein Reductase



Enoyl-Acyl-Carrier Protein Reductase (ENR) is an enzyme in the fatty acid synthesis. It is a target of anti-bacterial drugs such as triclosan (TCL). The images at the left and at the right correspond to one representative ENR, i.e. the crystal structure of Enoyl-Acyl-Carrier Protein Reductase from Bacillus subtilis (3oic).

3D Structures of Enoyl-Acyl-Carrier Protein Reductase
3oic – BsENR III – Bacillus subtilis 2ied - MtENR (mutant) - Mycobacterium tuberculosis 3oje – BcENR – Bacillus cereus

3gns, 3gnt – SaENR – Staphylococcus aureus

2p91 – ENR – Aquifex aeolicus

Enoyl-Acyl-Carrier Protein Reductase binary complex
3oew, 2x22, 2x23, 1eny, 1enz – MtENR+NAD 3of2 – MtENR (mutant)+NAD 2pr2, 2idz, 2h9i – MtENR+INH-NAPD

2aq8 – MtENR+NADH

2aqh, 2aqi, 2aqk – MtENR (mutant)+NADH 2ntj – MtENR+PTH-NAD 2ie0, 2ieb, 2nv6, 1zid – MtENR (mutant)+INH-NAPD

2ntv - ENR+PTH-NAD – Mycobacterium leprae

1vrw, 1v35 – PfENR+NAD 2nq8 – PfENR+INH-NAD 2foi – PfENR fragment+diaryl ether inhibitor

2pd3 – HpENR+TCL – Helicobacter pylori

1eno, 1enp - BnENR (mutant)+NAD – Brassica napus

Enoyl-Acyl-Carrier Protein Reductase ternary complex
3oid – BsENR III+NADP+TCL 3oif – BsENR I+NAD+TCL 3oig – BsENR I+NAD+INH

3fne, 3fnf, 3fng, 3fnh, 2b35, 1p45 – MtENR+NAD+TCL 2b36, 2b37 – MtENR+NAD+phenoxyphenol derivative

2nsd – MtENR+NAD+piperidine derivative

2h7i, 2h7l, 2h7m, 2h7n, 2h7p - MtENR+NAD+pyrrolidine derivative

1p44 - MtENR+NAD+indole derivative

1bvr - MtENR+NAD+fatty-acyl substrate

3ojf – BcENR+NADP+indole naphthyrididone

3lsy, 3lt0, 3lt1, 3lt2, 3lt4, 1uh5 – PfENR fragment+NAD+TCL – Plasmodium falciparum

2ol4, 2oos, 2op0, 2op1, 2o2y, 1zxb, 1zxl, 1zw1, 1zsn, 1nhg – PfENR+NAD+TCL 1nhw, 1nnu - PfENR+NAD+TCL analog

3gr6 – SaENR+NAD+TCL 2qio - ENR+NAD+TCL – Bacillus anthracis

2pd4 – HpENR+NAD+diclosan

1mfp, 1i30 - EcENR+NAD+indole derivative – Escherichia coli

1lx6, 1lxc - EcENR+NAD+amide derivative

1i2z - EcENR+NAD+imidazole derivative

1qsg - EcENR+NAD+TCL 1cwu – BnENR (mutant)+NAD+thienodiazaborine